OpenSesame provides courses in over 200 subjects (21,000 courses in all) primarily focused on business and professional users looking to pick up new skills and training to advance their careers. All courses are SCORM compliant.

Visitors browse the catalog or search for a course they need (anything from leadership skills for forklift driving), buy the number of seats they need (or pay for a yearly site-wide license for unlimited use), and start taking the course. User's progress is tracked so admins can see users' progress. The entire catalog can also be accessed via its API, allowing learning management system owners to access its catalog.

The company reports usage by "thousands of employees at dozens of companies in the US and around the world."